產(chǎn)品詳情

  • 產(chǎn)品名稱：UPF2RegulatorofNonsenseTranscriptsHomolog(Yeast)(UPF2)(N-Term)Peptide

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簡單介紹：
UPF2RegulatorofNonsenseTranscriptsHomolog(Yeast)(UPF2)(N-Term)Peptide
詳情介紹：
Blocked Antibody anti-UPF2 Regulator of Nonsense Transcripts Homolog (Yeast) (UPF2) (N-Term) antibody (ABIN2779085)
Sequence KAPEDKKKRL EDDKRKKEDK ERKKKDEEKV KAEEESKKKE EEEKKKHQEE
Characteristics This is a synthetic peptide designed for use in combination with anti-UPF2 Antibody,. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
Purification Purified
Background This gene encodes a protein that is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD). When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons. This protein is located in the perinuclear area. It interacts with translation release factors and the proteins that are functional homologs of yeast Upf1p and Upf3p. Two splice variants have been found for this gene, both variants encode the same protein.

Alias Symbols: DKFZp434D222, HUPF2, KIAA1408, MGC138834, MGC138835, RENT2, smg-3

Protein Interaction Partner: UPF1,DCP1B,DCP2,EIF1,EIF4A1,EIF4G1,EXOSC1,EXOSC10,EXOSC4,EXOSC6,EXOSC8,LSM1,MAP1A,MAP1LC3B,NOB1,PHB2,RPL5,RPS15,RPS25,SKIV2L2,SMG1,UPF1,UPF2,UPF3B,XRN1,XRN2,ZFP36,ZNF408,DCP2,EIF4A1,EXOSC10,EXOSC2,EXOSC4,LSM1,MAP1A,PARN,POLD1,RPS15,RPS25,SMG1,UPF1,UPF2,UP

Protein Size: 1272
Molecular Weight 148 kDa
Gene ID 26019
NCBI Accession NM_015542, NP_056357
UniProt Q9HAU5
Application Notes Each Investigator should determine their own optimal working dilution for specific applications.
Restrictions For Research Use only
Format Lyophilized
Reconstitution Add 100?μL of sterile PBS. Final peptide concentration is 1?mg/mL in PBS.
Concentration 1 mg/mL
Buffer Final peptide concentration is 1 mg/mL in PBS.
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.