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  • 產(chǎn)品名稱：Amyloidbeta(A4)PrecursorProtein(APP)(MiddleRegion)Peptide

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簡單介紹：
Amyloidbeta(A4)PrecursorProtein(APP)(MiddleRegion)Peptide
詳情介紹：
Blocked Antibody anti-APP antibody (Amyloid beta (A4) Precursor Protein) (Middle Region) (ABIN2778227)
Sequence SQVMREWEEA ERQAKNLPKA DKKAVIQHFQ EKVESLEQEA ANERQQLVET
Characteristics This is a synthetic peptide designed for use in combination with anti- APP Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
Purification Purified
Background This gene encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. In addition, two of the peptides are antimicrobial peptides, having been shown to have bacteriocidal and antifungal activities. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy). Multiple transcript variants encoding several different isoforms have been found for this gene.

Alias Symbols: AAA, AD1, PN2, ABPP, APPI, CVAP, ABETA, PN-II, CTFgamma

Protein Size: 714
Molecular Weight 85 kDa
Gene ID 351
NCBI Accession NM_001136130, NP_001129602
Research Area Signaling
Application Notes Each Investigator should determine their own optimal working dilution for specific applications.
Restrictions For Research Use only
Format Lyophilized
Reconstitution Add 100?μL of sterile PBS. Final peptide concentration is 1?mg/mL in PBS.
Concentration 1 mg/mL
Buffer Final peptide concentration is 1 mg/mL in PBS.
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.