產(chǎn)品詳情

  • 產(chǎn)品名稱：rChlorotoxin(CTX,Cltx)

  • 產(chǎn)品型號(hào)：
  • 產(chǎn)品廠商：BioLeaf
  • 產(chǎn)品文檔：
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簡單介紹：
rChlorotoxin(CTX,Cltx)
詳情介紹：
Sequence MCMPCFTTDH QMARKCDDCC GGKGRGKCYG PQCLCR.
Specificity Chlorotoxin blocks small conductance Cl- channels of epithelial cells and also blocks Cl- channels expressed in gliomas1,2.
Characteristics Source: Leiurus quinquestriatus (Egyptian scorpion).
Molecular formula: C158H249N53O47S11.
Disulfide bonds between Cys2-Cys19, Cys5-Cys28, Cys16-Cys33 and Cys20 - Cys35.
Purity > 98 %
Molecular Weight 3996
Application Notes 50-600 nM
Restrictions For Research Use only
Format Lyophilized
Reconstitution Any aqueous buffer. Centrifuge all product preparations before use (10000 x g 5 min).
Concentration after reconstitution: Dissolving 50g in 1.251ml will provide a stock solution of 10 M.
Handling Advice Soluble in Water.
Product cited in: McFerrin, Sontheimer: "A role for ion channels in glioma cell invasion." in: Neuron glia biology, Vol. 2, Issue 1, pp. 39-49, 2008 (PubMed).

Deshane, Garner, Sontheimer: "Chlorotoxin inhibits glioma cell invasion via matrix metalloproteinase-2." in: The Journal of biological chemistry, Vol. 278, Issue 6, pp. 4135-44, 2003 (PubMed).

Lyons, ONeal, Sontheimer: "Chlorotoxin, a scorpion-derived peptide, specifically binds to gliomas and tumors of neuroectodermal origin." in: Glia, Vol. 39, Issue 2, pp. 162-73, 2002 (PubMed).

Soroceanu, Manning, Sontheimer: "Modulation of glioma cell migration and invasion using Cl(-) and K(+) ion channel blockers." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 19, Issue 14, pp. 5942-54, 1999 (PubMed).

Ullrich, Bordey, Gillespie, Sontheimer: "Expression of voltage-activated chloride currents in acute slices of human gliomas." in: Neuroscience, Vol. 83, Issue 4, pp. 1161-73, 1998 (PubMed).

Soroceanu, Gillespie, Khazaeli, Sontheimer: "Use of chlorotoxin for targeting of primary brain tumors." in: Cancer research, Vol. 58, Issue 21, pp. 4871-9, 1998 (PubMed).

Ullrich, Gillespie, Sontheimer: "Human astrocytoma cells express a unique chloride current." in: Neuroreport, Vol. 7, Issue 5, pp. 1020-4, 1996 (PubMed).

DeBin, Strichartz: "Chloride channel inhibition by the venom of the scorpion Leiurus quinquestriatus." in: Toxicon : official journal of the International Society on Toxinology, Vol. 29, Issue 11, pp. 1403-8, 1992 (PubMed).