產(chǎn)品詳情

  • 產(chǎn)品名稱：rKaliotoxin-1(KTX-1)

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  • 產(chǎn)品廠商：BioLeaf
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rKaliotoxin-1(KTX-1)
詳情介紹：
Sequence GVEINVKCSG SPQCLKPCKD AGMRFGKCMN RKCHCTP.
Specificity Kaliotoxin-1 is a potent inhibitor of large conductance Ca2+- activated K+ channels (BKCa). Kaliotoxin-1 also binds the dendrotoxin sensitive voltage-dependent K+ channel.
Characteristics Source: Androctonus mauretanicus mauretanicus (Scorpion).
Molecular formula: C165H277N53O48S8.
Disulfide bonds between Cys8-Cys28, Cys14-Cys33, and Cys18-Cys35.
Purity > 98 %
Molecular Weight 4022
Application Notes 10-100 nM
Comment

K+ channel toxin -KTx 3.1
Restrictions For Research Use only
Format Lyophilized
Reconstitution Any aqueous buffer. Centrifuge all product preparations before use (10000 x g 5 min).
Concentration after reconstitution: Dissolving 50 g in 1.243 ml will provide a stock solution of 10 M.
Handling Advice Soluble in Water.
Product cited in: Rodríguez de la Vega, Possani: "Current views on scorpion toxins specific for K+-channels." in: Toxicon : official journal of the International Society on Toxinology, Vol. 43, Issue 8, pp. 865-75, 2004 (PubMed).

Mourre, Chernova, Martin-Eauclaire, Bessone, Jacquet, Gola, Alper, Crest: "Distribution in rat brain of s of kaliotoxin, a blocker of Kv1.1 and Kv1.3 alpha-subunits." in: The Journal of pharmacology and experimental therapeutics, Vol. 291, Issue 3, pp. 943-52, 1999 (PubMed).

Grissmer, Nguyen, Aiyar, Hanson, Mather, Gutman, Karmilowicz, Auperin, Chandy: "Pharmacological characterization of five cloned voltage-gated K+ channels, types Kv1.1, 1.2, 1.3, 1.5, and 3.1, stably expressed in mammalian cell lines." in: Molecular pharmacology, Vol. 45, Issue 6, pp. 1227-34, 1994 (PubMed).

Crest, Jacquet, Gola, Zerrouk, Benslimane, Rochat, Mansuelle, Martin-Eauclaire: "Kaliotoxin, a novel peptidyl inhibitor of neuronal BK-type Ca(2+)-activated K+ channels characterized from Androctonus mauretanicus mauretanicus venom." in: The Journal of biological chemistry, Vol. 267, Issue 3, pp. 1640-7, 1992 (PubMed).