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                            產(chǎn)品詳情
                        
      
                        
      
                            
      
                                
                            
      
                            
      
                                
                                
                            
      
                            

                            
      
    
      
    
      
        
      
    
      
            
      

                
      
                    
                    
        
                          
      • 產(chǎn)品名稱：rAgitoxin-2(AgTx2)
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      • 產(chǎn)品型號：
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      • 產(chǎn)品廠商：BioLeaf
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      • 產(chǎn)品文檔：
                          
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                    你添加了1件商品 查看購物車
                    
      

                
      
            
      
    
      

    
      
        
      
            簡單介紹：
        
      
        
      
            rAgitoxin-2(AgTx2)
        
      
    
      

    
      
        
      
            詳情介紹：
        
      
        
      
            
      
                
      
                    
                        
                        
                    
                    
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
      
                                                                                    
                                                Sequence
                                            
                                        
                                                                                    
                                            
                                                GVPINVSCTG SPQCIKPCKD AGMRFGKCMN RKCHCTPK.
                                                                                            
                                                                            
      
                                                                                                                                                                                                                                                                                                                                                                                                                                                    
      
                                                                                    
                                                Specificity
                                            
                                        
                                                                                    
                                            
                                                Agitoxin-2 is a blocker of Shaker voltage-gated K+ channels as well as the mammalian homologues of Shaker.
                                                                                            
                                                                            
      
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
      
                                                                                    
                                                Characteristics
                                            
                                        
                                                                                    
                                            
                                                Source: Leiurus quinquestriatus hebraeus (Yellow scorpion).
      Molecular formula: C169H278N54O48S8.
      Disulfide bonds between Cys8-Cys28, Cys14-Cys33, and Cys18-Cys35.
                                                                                                  		
                                                                            
      
                                                                                                                                                                                                                                                            
      
                                                                                    
                                                Purity
                                            
                                        
                                                                                    
                                            
                                                > 98 %
                                                                                            
                                                                            
      
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
                          
                
      
            
      
                                                                                    
      
                
      
                    
                        
                        
                    
                    
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
      
                                                                                    
                                                Molecular Weight
                                            
                                        
                                                                                    
                                            
                                                4091
                                                                                            
                                                                            
      
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
                          
                
      
            
      
                                                                        
      
                
      
                    
                        
                        
                    
                    
                                                                                                                                                        
      
                                                                                    
                                                Application Notes
                                            
                                        
                                                                                    
                                            
                                                50 pM - 10 nM
                                                                                            
                                                                            
      
                                                                                                                                                                
      
                                                                                    
                                                Comment
                                            
                                        
                                                                                    
                                            
                                                
      K+ channel toxin -KTx 3.2
      
                                                                                                  		
                                                                            
      
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
      
                                                                                    
                                                Restrictions
                                            
                                        
                                                                                    
                                            
                                                For Research Use only
                                                                                            
                                                                            
      
                                                                                    
                          
                
      
            
      
                                                                                                            
      
                
      
                    
                        
                        
                    
                    
                                                                                                                                                        
      
                                                                                    
                                                Format
                                            
                                        
                                                                                    
                                            
                                                Lyophilized
                                                                                            
                                                                            
      
                                                                                                                                                                
      
                                                                                    
                                                Reconstitution
                                            
                                        
                                                                                    
                                            
                                                Any aqueous buffer. Centrifuge all product preparations before use (10000 x g 5 min). 
      Concentration after reconstitution: Dissolving 50g in 1.222ml will provide a stock solution of 10 M.
                                                                                                  		
                                                                            
      
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
      
                                                                                    
                                                Handling Advice
                                            
                                        
                                                                                    
                                            
                                                Soluble in Water.
                                                                                            
                                                                            
      
                                                                                                                                                                                                                                                                                                                                                                        
                          
                
      
            
      
                                                                                                                                        
      
                
      
                    
                        
                        
                    
                    
                                                                                                                        
      
                                                                                                                                                                            
                                                                                                        Product cited in:
                                                
                                                
                                                                                                     Cayabyab, Khanna, Jones, Schlichter: "Suppression of the rat microglia Kv1.3 current by src-family tyrosine kinases and oxygen/glucose deprivation."                                                    in: The European journal of neuroscience, Vol. 12, Issue 6, pp. 1949-60, 2000                                                         (PubMed).                                                    
                                                                                                        

      
                                                                                                     Garcia, Garcia-Calvo, Hidalgo, Lee, MacKinnon: "Purification and characterization of three inhibitors of voltage-dependent K+ channels from Leiurus quinquestriatus var. hebraeus venom."                                                    in: Biochemistry, Vol. 33, Issue 22, pp. 6834-9, 1994                                                         (PubMed).