產(chǎn)品詳情

  • 產(chǎn)品名稱：FasLigandInhibitorPeptide

  • 產(chǎn)品型號(hào)：
  • 產(chǎn)品廠商：KamiyaBiomedical
  • 產(chǎn)品文檔：
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簡單介紹：
FasLigandInhibitorPeptide
詳情介紹：
Specificity Inhibits the apoptosis-inducing activity of Fas Ligand. Binds FasL (APO-1L, CD95L, CD178).
Characteristics Extracellular domain of human Fas (aa. 7-154) fused to Fc portion of human IgG1.
Purity 95 % as determined by SDS-PAGE
Endotoxin Level <0.1 eu="" μg="" purified="" protein="" as="" determined="" by="" lal="" test.="" <="" td="">
Background Fas is a 45 kDa type I transmembrane protein belonging to the TNF receptor family. Fas contains 3 cysteine-rich repeats in the extracellular portion and a cytoplasmic motif called the `death domain' (DD). Death signals are triggered upon binding to its trimeric ligand FasL which induces oligomerization of Fas. The DD associates with FADD, which in turn connects to aspartate-specific proteases (caspases) that are implicated as mediators of most types of apoptotic cell death. Synonyms: APO-1, CD95, TNFRSF 6
Molecular Weight 45 kDa
Application Notes Functional Application: Inhibition of FAS Ligand activity in human and mouse: The apoptosis-inducing activity of FasL is inhibited by concentrations of 20-100 μg/mL of the fusion protein. Concentrations of Fas Ligand Inhibitor required to inhibit may vary depending on the cell viability and on the concentrations of sFasL used to kill the cells.
Restrictions For Research Use only
Format Lyophilized
Reconstitution Reconstitute with 50 μL sterile water to produce a 1 mg/mL solution in PBS. Further dilutions should be made with medium containing 5% fetal calf serum (FCS) or a carrier protein.
Buffer PBS
Storage -20 °C