產(chǎn)品詳情

  • 產(chǎn)品名稱：MLN8237(Alisertib)

  • 產(chǎn)品型號(hào)：
  • 產(chǎn)品廠商：TargetMol
  • 產(chǎn)品文檔：
你添加了1件商品 查看購(gòu)物車
簡(jiǎn)單介紹：
MLN8237(Alisertib)
詳情介紹：
Purpose Alisertib is a second-generation, orally bioavailable, highly selective small molecule inhibitor of the serine/threonine protein kinase Aurora A kinase with potential antineoplastic activity. Alisertib binds to and inhibits Aurora A kinase, which may result in disruption of the assembly of the mitotic spindle apparatus, disruption of chromosome segregation, and inhibition of cell proliferation. Aurora A kinase localizes to the spindle poles and to spindle microtubules during mitosis, and is thought to regulate spindle assembly. Aberrant expression of Aurora kinases occurs in a wide variety of cancers, including colon and breast cancers.
Characteristics Tradename: Alisertib
Target: Aurora Kinase inhibitor
Receptor: Aurora A, Aurora B
Purification All the products are sent with COA, HPLC and NMR inspection report to guarantee the quality.
Purity 97?% +
Formula C27H20ClFN4O4
Solubility Soluble in DMSO
Molecular Weight 518.92 g/mol
CAS-No 1028486-01-2
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Format Solid
Storage -20 °C
Storage Comment For the majority of compounds, they could be dissolved in DMSO or other organic solvent.
Their stock solution can be stored at -20°C for up to 3 months and aliquoted for sampling convenience.
Several freeze/thaw cycles should not damage the activity of our small molecule products.
However, in many instances the aqueous solutions of some compounds need to be made fresh and cannot be stored. For these compounds, their solution should be prepared just before use and stored no longer than 24 hours.
Expiry Date 24 months