產(chǎn)品詳情
簡(jiǎn)單介紹:
PF-4708671
詳情介紹:
Purpose | PF-4708671 is a cell-permeable inhibitor of p70 ribosomal S6 kinase (S6K1 isoform) with Ki/IC50 of 20 nM/160 nM in cell-free assays, 400-fold greater selectivity for S6K1 than S6K2, and 4- and >20-fold selectivity for S6K1 than MSK1 and RSK1/2, respectively. First S6K1-specific inhibitor to be reported. |
Characteristics |
Target: S6 Kinase inhibitor Receptor: p70 S6K1 |
Purification | All the products are sent with COA, HPLC and NMR inspection report to guarantee the quality. |
Purity | 98?% |
Formula | C19H21F3N6 |
Permeability | Cell-permeable |
Solubility | DMSO > 10mM |
Molecular Weight | 390.41 g/mol |
CAS-No | 1255517-76-0 |
Application Notes | Optimal working dilution should be determined by the investigator. |
Restrictions | For Research Use only |
Format | Solid |
Storage | -20 °C |
Storage Comment |
For the majority of compounds, they could be dissolved in DMSO or other organic solvent. Their stock solution can be stored at -20°C for up to 3 months and aliquoted for sampling convenience. Several freeze/thaw cycles should not damage the activity of our small molecule products. However, in many instances the aqueous solutions of some compounds need to be made fresh and cannot be stored. For these compounds, their solution should be prepared just before use and stored no longer than 24 hours. |
Expiry Date | 24 months |