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  • 產(chǎn)品名稱：AZD1208

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  • 產(chǎn)品廠商：TargetMol
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AZD1208
詳情介紹：
Purpose AZD1208 is a novel, orally bioavailable, highly selective PIM kinase inhibitor with single nanomolar potency against all three PIM kinases and is currently undergoing Phase I testing and dose escalation studies in AML. AZD1208 suppresses the growth of MOLM 16 and KG 1 xenograft tumors in vivo in a dosedependent manner. Furthermore, AZD1208 leads to potent inhibition of colony development of primary AML cells from bone marrow aspirates and downregulates the phosphorylation of PIM goals. AZD1208 inhibits the growth of several AML cell lines and sensitivity correlates with the level of PIM1 expression, STAT5 activation and presence of protein tyrosine kinase mutation. AZD1208 causes cell cycle arrest and apoptosis in MOLM-16 cells in culture.
Characteristics Target: Pim inhibitor
Receptor: Pim1,2,3
Purification All the products are sent with COA, HPLC and NMR inspection report to guarantee the quality.
Purity 97?% +
Formula C21H21N3O2S
Solubility 10 mM in DMSO
Molecular Weight 379.48 g/mol
CAS-No 1204144-28-4
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Format Solid
Storage -20 °C
Storage Comment For the majority of compounds, they could be dissolved in DMSO or other organic solvent.
Their stock solution can be stored at -20°C for up to 3 months and aliquoted for sampling convenience.
Several freeze/thaw cycles should not damage the activity of our small molecule products.
However, in many instances the aqueous solutions of some compounds need to be made fresh and cannot be stored. For these compounds, their solution should be prepared just before use and stored no longer than 24 hours.
Expiry Date 24 months