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  • 產(chǎn)品名稱：AG-337,Nolatrexed2HCl

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  • 產(chǎn)品廠商：TargetMol
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簡單介紹：
AG-337,Nolatrexed2HCl
詳情介紹：
Purpose Nolatrexed Dihydrochloride is the dihydrochloride salt of nolatrexed, a water-soluble lipophilic quinazoline folate analog with antineoplastic activity. Nolatrexed occupies the folate of thymidylate synthase, resulting in inhibition of thymidylate synthase activity and thymine nucleotide synthesis with subsequent inhibition of DNA replication, DNA damage, S-phase cell cycle arrest, and caspase-dependent apoptosis. This agent also exhibits radiosensitizing activity.
Characteristics Target: Thymidylate synthase inhibitor
Receptor: Thymidylate synthase
Purification All the products are sent with COA, HPLC and NMR inspection report to guarantee the quality.
Purity 100?%
Formula C14H14Cl2N4OS
Solubility DMSO > 10 mM
Molecular Weight 357.26 g/mol
CAS-No 152946-68-4
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Format Solid
Storage -20 °C
Storage Comment For the majority of compounds, they could be dissolved in DMSO or other organic solvent.
Their stock solution can be stored at -20°C for up to 3 months and aliquoted for sampling convenience.
Several freeze/thaw cycles should not damage the activity of our small molecule products.
However, in many instances the aqueous solutions of some compounds need to be made fresh and cannot be stored. For these compounds, their solution should be prepared just before use and stored no longer than 24 hours.
Expiry Date 24 months