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  • 產(chǎn)品名稱：LDK378(Ceritinib)

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  • 產(chǎn)品廠商：TargetMol
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簡單介紹：
LDK378(Ceritinib)
詳情介紹：
Purpose Ceritinib is an orally available inhibitor of the receptor tyrosine kinase activity of anaplastic lymphoma kinase (ALK) with antineoplastic activity. Upon administration, ceritinib binds to and inhibits wild-type ALK kinase, ALK fusion proteins and ALK point mutation variants. Inhibition of ALK leads to both the disruption of ALK-mediated signaling and the inhibition of cell growth in ALK-overexpressing tumor cells. ALK belongs to the insulin receptor superfamily and plays an important role in nervous system development. ALK dysregulation and gene rearrangements are associated with a variety of tumor cell types.
Characteristics Tradename: Ceritinib
Target: TGF-beta/Smad inhibitor, IGF-1R inhibitor
Receptor: ALK,IR, IGF-1R
Status: JAN,USAN, USP
Purification All the products are sent with COA, HPLC and NMR inspection report to guarantee the quality.
Purity 100?%
Formula C28H36ClN5O3S
Solubility DMSO > 10mM
Molecular Weight 558.14 g/mol
CAS-No 1032900-25-6
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Format Solid
Storage -20 °C
Storage Comment For the majority of compounds, they could be dissolved in DMSO or other organic solvent.
Their stock solution can be stored at -20°C for up to 3 months and aliquoted for sampling convenience.
Several freeze/thaw cycles should not damage the activity of our small molecule products.
However, in many instances the aqueous solutions of some compounds need to be made fresh and cannot be stored. For these compounds, their solution should be prepared just before use and stored no longer than 24 hours.
Expiry Date 24 months