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  • 產(chǎn)品名稱：XL184(Cabozantinibmalate)

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  • 產(chǎn)品廠商：TargetMol
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XL184(Cabozantinibmalate)
詳情介紹：
Purpose Cabozantinib S-malate is the s-malate salt form of cabozantinib, an orally bioavailable, small molecule receptor tyrosine kinase (RTK) inhibitor with potential antineoplastic activity. Cabozantinib strongly binds to and inhibits several RTKs, which are often overexpressed in a variety of cancer cell types, including hepatocyte growth factor receptor (MET), RET (rearranged during transfection), vascular endothelial growth factor receptor types 1 (VEGFR-1), 2 (VEGFR-2), and 3 (VEGFR-3), mast/stem cell growth factor (KIT), FMS-like tyrosine kinase 3 (FLT-3), TIE-2 (TEK tyrosine kinase, endothelial), tropomyosin-related kinase B (TRKB) and AXL. This may result in an inhibition of both tumor growth and angiogenesis, and eventually lead to tumor regression.
Characteristics Tradename: Cabozantinib S-malate
Target: VEGFR inhibitor
Receptor: VEGFR3/FLT4
Purification All the products are sent with COA, HPLC and NMR inspection report to guarantee the quality.
Purity 98?%
Formula C32H30FN3O10
Solubility Soluble in DMSO
Molecular Weight 635.59 g/mol
CAS-No 1140909-48-3
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Format Solid
Storage -20 °C
Storage Comment For the majority of compounds, they could be dissolved in DMSO or other organic solvent.
Their stock solution can be stored at -20°C for up to 3 months and aliquoted for sampling convenience.
Several freeze/thaw cycles should not damage the activity of our small molecule products.
However, in many instances the aqueous solutions of some compounds need to be made fresh and cannot be stored. For these compounds, their solution should be prepared just before use and stored no longer than 24 hours.
Expiry Date 24 months