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  • 產(chǎn)品名稱：Sorafenib

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Sorafenib
詳情介紹：
Purpose Sorafenib (rINN), marketed as Nexavar by Bayer, is a drug approved for the treatment of advanced renal cell carcinoma (primary kidney cancer). It has also received "Fast Track" designation by the FDA for the treatment of advanced hepatocellular carcinoma (primary liver cancer), and has since performed well in Phase III trials. Sorafenib is a small molecular inhibitor of Raf kinase, PDGF (platelet-derived growth factor), VEGF receptor 2 & 3 kinases and c Kit the receptor for Stem cell factor. A growing number of drugs target most of these pathways. The originality of Sorafenib lays in its simultaneous targeting of the Raf/Mek/Erk pathway.
Characteristics Tradename: Bay 43-9006
Source of Compound: synthetic
Target: Raf inhibitor, VEGFR inhibitor, PDGFR inhibitor
Receptor: Raf, VEGFR, PDGFR
Purification All the products are sent with COA, HPLC and NMR inspection report to guarantee the quality.
Purity 99?%
Formula C21H16ClF3N4O3
Solubility DMSO 63 mg/mL warmed,Water <1 mg="" ml="" <="" td="">
Molecular Weight 464.83 g/mol
CAS-No 284461-73-0
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Format Solid
Storage -20 °C
Storage Comment For the majority of compounds, they could be dissolved in DMSO or other organic solvent.
Their stock solution can be stored at -20°C for up to 3 months and aliquoted for sampling convenience.
Several freeze/thaw cycles should not damage the activity of our small molecule products.
However, in many instances the aqueous solutions of some compounds need to be made fresh and cannot be stored. For these compounds, their solution should be prepared just before use and stored no longer than 24 hours.
Expiry Date 24 months