產(chǎn)品詳情

  • 產(chǎn)品名稱：Tivozanib(AV-951)

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  • 產(chǎn)品廠商：TargetMol
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Tivozanib(AV-951)
詳情介紹：
Purpose Tivozanib is an orally bioavailable inhibitor of vascular endothelial growth factor receptors (VEGFRs) 1, 2 and 3 with potential antiangiogenic and antineoplastic activities. Tivozanib binds to and inhibits VEGFRs 1, 2 and 3, which may result in the inhibition of endothelial cell migration and proliferation, inhibition of tumor angiogenesis and tumor cell death. VEGFR tyrosine kinases, frequently overexpressed by a variety of tumor cell types, play a key role in angiogenesis.
Characteristics Target: c-Met inhibitor, VEGFR inhibitor
Receptor: c-MET,VEGFR1/2/3
Purification All the products are sent with COA, HPLC and NMR inspection report to guarantee the quality.
Purity 99.30?%
Formula C22H19ClN4O5
Solubility Soluble in DMSO
Molecular Weight 454.86 g/mol
CAS-No 475108-18-0
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Format Solid
Storage -20 °C
Storage Comment For the majority of compounds, they could be dissolved in DMSO or other organic solvent.
Their stock solution can be stored at -20°C for up to 3 months and aliquoted for sampling convenience.
Several freeze/thaw cycles should not damage the activity of our small molecule products.
However, in many instances the aqueous solutions of some compounds need to be made fresh and cannot be stored. For these compounds, their solution should be prepared just before use and stored no longer than 24 hours.
Expiry Date 24 months