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  • 產(chǎn)品名稱：Afatinib(BIBW2992)

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  • 產(chǎn)品廠商：TargetMol
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Afatinib(BIBW2992)
詳情介紹：
Purpose Afatinib is an orally bioavailable anilino-quinazoline derivative and inhibitor of the receptor tyrosine kinase (RTK) epidermal growth factor receptor (ErbB, EGFR) family, with antineoplastic activity. Upon administration, afatinib selectively and irreversibly binds to and inhibits the epidermal growth factor receptors 1 (ErbB1, EGFR), 2 (ErbB2, HER2), and 4 (ErbB4, HER4), and certain EGFR mutants, including those caused by EGFR exon 19 deletion mutations or exon 21 (L858R) mutations. This may result in the inhibition of tumor growth and angiogenesis in tumor cells overexpressing these RTKs. Additionally, afatinib inhibits the EGFR T790M gatekeeper mutation which is resistant to treatment with first-generation EGFR inhibitors. EGFR, HER2 and HER4 are RTKs that belong to the EGFR superfamily, they play major roles in both tumor cell proliferation and tumor vascularization and are overexpressed in many cancer cell types.
Characteristics Target: EGFR inhibitor
Receptor: EGFR
Purification All the products are sent with COA, HPLC and NMR inspection report to guarantee the quality.
Purity 97?% +
Formula C24H25ClFN5O3
Solubility Soluble in DMSO
Molecular Weight 485.94 g/mol
CAS-No 439081-18-2
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Format Solid
Storage -20 °C
Storage Comment For the majority of compounds, they could be dissolved in DMSO or other organic solvent.
Their stock solution can be stored at -20°C for up to 3 months and aliquoted for sampling convenience.
Several freeze/thaw cycles should not damage the activity of our small molecule products.
However, in many instances the aqueous solutions of some compounds need to be made fresh and cannot be stored. For these compounds, their solution should be prepared just before use and stored no longer than 24 hours.
Expiry Date 24 months