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  • 產(chǎn)品名稱：ImatinibMesylate(STI571)

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  • 產(chǎn)品廠商：TargetMol
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ImatinibMesylate(STI571)
詳情介紹：
Purpose Imatinib mesylate is a tyrosine kinase inhibitor IC50 value of 100 nM, 100 nM, 600 nM for v-Abl, c-kit, PDGFR, respectively [1]. Tyrosine kinase is an enzyme which is a subclass of protein kinase and plays an important role in transferring a phosphate group from ATP to a protein in cells. It is shown that tyrosine kinase plays a pivotal role in the management of disorders in which activation of c-Abl, PDGFR, or c-Kit signaling. Recently, the role of tyrosine kinases in the modulation of growth factor signaling are received more and more attention and gradually become an especial important target.
Characteristics Tradename: Glivec, CGP-57148B, STI-571
Source of Compound: synthetic
Target: Bcr-Abl inhibitor,c-kit inhibitor, PDGFR inhibitor
Receptor: v-Abl, c-Kit, PDGFR
Status: USP
Purification All the products are sent with COA, HPLC and NMR inspection report to guarantee the quality.
Purity 99?%
Formula C29H31N7O.CH4SO3
Solubility DMSO > 10 mM
Molecular Weight 589.71 g/mol
CAS-No 220127-57-1
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Format Solid
Storage -20 °C
Storage Comment For the majority of compounds, they could be dissolved in DMSO or other organic solvent.
Their stock solution can be stored at -20°C for up to 3 months and aliquoted for sampling convenience.
Several freeze/thaw cycles should not damage the activity of our small molecule products.
However, in many instances the aqueous solutions of some compounds need to be made fresh and cannot be stored. For these compounds, their solution should be prepared just before use and stored no longer than 24 hours.
Expiry Date 24 months