產(chǎn)品詳情

  • 產(chǎn)品名稱：Afatinib(BIBW2992)Dimaleate

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  • 產(chǎn)品廠商：TargetMol
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Afatinib(BIBW2992)Dimaleate
詳情介紹：
Purpose Afatinib (BIBW2992) irreversibly inhibits EGFR/HER2 including EGFR(wt), EGFR(L858R), EGFR(L858R/T790M) and HER2 with IC50 of 0.5 nM, 0.4 nM, 10 nM and 14 nM, respectively, 100-fold more active against Gefitinib-resistant L858R-T790M EGFR mutant.
Characteristics Target: EGFR inhibitor, HER2 inhibitor
Receptor: EGFR,EGFR mutant forms, HER2
Purification All the products are sent with COA, HPLC and NMR inspection report to guarantee the quality.
Purity 98?%
Formula C32H33ClFN5O11
Solubility DMSO > 10mM
Molecular Weight 718.08 g/mol
CAS-No 850140-73-7
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Format Solid
Storage -20 °C
Storage Comment For the majority of compounds, they could be dissolved in DMSO or other organic solvent.
Their stock solution can be stored at -20°C for up to 3 months and aliquoted for sampling convenience.
Several freeze/thaw cycles should not damage the activity of our small molecule products.
However, in many instances the aqueous solutions of some compounds need to be made fresh and cannot be stored. For these compounds, their solution should be prepared just before use and stored no longer than 24 hours.
Expiry Date 24 months