產(chǎn)品詳情

  • 產(chǎn)品名稱：PS-1145

  • 產(chǎn)品型號(hào)：
  • 產(chǎn)品廠商：Biovision
  • 產(chǎn)品文檔：
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簡單介紹：
PS-1145
詳情介紹：
Characteristics

PubChem CID: 9949093
Molecular Formula: C??H??ClN?O
Cell Premeable: Yes

Salt form: No

PS-1145 is a potent and selective IκB kinase (IKK) inhibitor (IC?? = 100 nM). Has no effect on PKA, PKC and CKII activity. PS-1145 efficiently inhibits both basal and induced NF-κB activity in PC cells. Enhances TNF-α-induced apoptosis in a multiple myeloma cell line.

Smiles: C1=CC(=CN=C1)C(=O)NC2=C3C(=CC(=C2)Cl)C4=C(N3)C=NC=C4

InChi: InChI=1S/C17H11ClN4O/c18-11-6-13-12-3-5-20-9-15(12)21-16(13)14(7-11)22-17(23)10-2-1-4-19-8-10/h1-9,21H,(H,22,23)

Inchi Key: JZRMBDHPALEPDM-UHFFFAOYSA-N
Purity ≥ 98?% by HPLC
Chemical Name N-(6-chloro-9H-pyrido[3,4-b]indol-8-yl)nicotinamide
Formula C??H??ClN?O
Permeability Cell-permeable
Background Synonyms: N-(6-chloro-9H-pyrido[3,4-b]indol-8-yl)nicotinamide
Molecular Weight 322.75 g/mol
CAS-No 431898-65-6
Restrictions For Research Use only
Format Solid
Handling Advice Protect from air and light
Storage -20 °C
Expiry Date 36 months