產(chǎn)品詳情

  • 產(chǎn)品名稱：LY-2835219

  • 產(chǎn)品型號：
  • 產(chǎn)品廠商：Biovision
  • 產(chǎn)品文檔：
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簡單介紹：
LY-2835219
詳情介紹：
Characteristics

PubChem CID: 71576678
Molecular Formula: C??H??F?N?.CH?O?S
Cell Premeable: Yes

Salt form: No

LY-2835219 is a potent and selective inhibitor of CDK4 and CDK6 with IC?? of 2 nM and 10 nM, respectively. LY-2835219 inhibits the proliferation of Rb-positive tumor cells and demonstrates dose-dependent growth inhibition in ER+ breast cancer models.

Smiles: CCN1CCN(CC1)CC2=CN=C(C=C2)NC3=NC=C(C(=N3)C4=CC5=C(C(=C4)F)N=C(N5C(C)C)C)F.CS(=O)(=O)O

InChi: InChI=1S/C27H32F2N8.CH4O3S/c1-5-35-8-10-36(11-9-35)16-19-6-7-24(30-14-19)33-27-31-15-22(29)25(34-27)20-12-21(28)26-23(13-20)37(17(2)3)18(4)32-26,1-5(2,3)4/h6-7,12-15,17H,5,8-11,16H2,1-4H3,(H,30,31,33,34),1H3,(H,2,3,4)

Inchi Key: NCJPFQPEVDHJAZ-UHFFFAOYSA-N
Purity ≥ 98?% by HPLC
Chemical Name N-(5-((4-ethylpiperazin-1-yl)methyl)pyridin-2-yl)-5-fluoro-4-(4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazol-6-yl)pyrimidin-2-amine; Abemaciclib
Formula C??H??F?N?.CH?O?S
Permeability Cell-permeable
Background Synonyms: N-(5-((4-ethylpiperazin-1-yl)methyl)pyridin-2-yl)-5-fluoro-4-(4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazol-6-yl)pyrimidin-2-amine, Abemaciclib
Molecular Weight 602.7 g/mol
CAS-No 1231930-82-7
Restrictions For Research Use only
Format Solid
Handling Advice Protect from air and moisture
Storage -20 °C
Expiry Date 36 months