產(chǎn)品詳情

  • 產(chǎn)品名稱：Ro48-8071fumarate

  • 產(chǎn)品型號(hào)：
  • 產(chǎn)品廠商：Biovision
  • 產(chǎn)品文檔：
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簡(jiǎn)單介紹：
Ro48-8071fumarate
詳情介紹：
Characteristics

PubChem CID: 9959583
Molecular Formula: C??H??BrFNO?.C?H?O?
Cell Premeable: Yes

Salt form: No

Ro 48-8071 is a selective 2,3-Oxidosqualene:lanosterol cyclase (OSC) inhibitor (IC?? = 6.5 nM), blocks cholesterol synthesis in HepG2 cells. Ro 48-8071 exerts strong anti-angiogenic activity by impairing endothelial cell adhesion and migration, and by blocking vessel formation in angiogenesis assays.

Smiles: CN(CCCCCCOC1=CC(=C(C=C1)C(=O)C2=CC=C(C=C2)Br)F)CC=C.C(=CC(=O)O)C(=O)O

InChi: InChI=1S/C23H27BrFNO2.C4H4O4/c1-3-14-26(2)15-6-4-5-7-16-28-20-12-13-21(22(25)17-20)23(27)18-8-10-19(24)11-9-18,5-3(6)1-2-4(7)8/h3,8-13,17H,1,4-7,14-16H2,2H3,1-2H,(H,5,6)(H,7,8)/b,2-1+

Inchi Key: XCYAYLWZCRGKDS-WLHGVMLRSA-N
Purity ≥ 98?% by HPLC
Chemical Name (4-Bromophenyl)[2-fluoro-4-[[6-(methyl-2-propen-1-ylamino)hexyl]oxy]phenyl]methanone fumarate
Formula C??H??BrFNO?.C?H?O?
Permeability Cell-permeable
Background Synonyms: (4-Bromophenyl)[2-fluoro-4-[[6-(methyl-2-propen-1-ylamino)hexyl]oxy]phenyl]methanone fumarate
Molecular Weight 564.44 g/mol
CAS-No 189197-69-1
Restrictions For Research Use only
Format Solid
Handling Advice Protect from air and moisture
Storage -20 °C
Expiry Date 36 months