產(chǎn)品詳情

  • 產(chǎn)品名稱：MCC950sodium

  • 產(chǎn)品型號：
  • 產(chǎn)品廠商：Biovision
  • 產(chǎn)品文檔：
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簡單介紹：
MCC950sodium
詳情介紹：
Characteristics

PubChem CID: 91826093
Molecular Formula: C??H??N?NaO?S
Cell Premeable: Yes

Salt form: No

MCC950 sodium is a potent and selective NLRP3 inflammasome inhibitor. It blocks the release of IL-1β in macrophages primed with LPS and activated with ATP or nigericin, but it does not inhibit NLRP1, NLRC4, AIM2, TLR2 signaling or priming of NLRP3. Also glutathione S-transferase omega 1 inhibitor. Potential therapeutic agent for NLRP3-associated syndromes, including autoinflammatory and autoimmune diseases.

Smiles: CC(C)(C1=COC(=C1)S(=O)(=O)[N-]C(=O)NC2=C3CCCC3=CC4=C2CCC4)O.[Na+]

InChi: InChI=1S/C20H24N2O5S.Na/c1-20(2,24)14-10-17(27-11-14)28(25,26)22-19(23)21-18-15-7-3-5-12(15)9-13-6-4-8-16(13)18,/h9-11,24H,3-8H2,1-2H3,(H2,21,22,23),/q,+1/p-1

Inchi Key: LFQQNXFKPNZRFT-UHFFFAOYSA-M
Purity ≥ 98?% by HPLC
Chemical Name N-[[(1,2,3,5,6,7-Hexahydro-s-indacen-4-yl)amino]carbonyl]-4-(1-hydroxy-1-methylethyl)-2-furansulfonamide sodium salt; CP-456,773; CRID3
Formula C??H??N?NaO?S
Permeability Cell-permeable
Background Synonyms: N-[[(1,2,3,5,6,7-Hexahydro-s-indacen-4-yl)amino]carbonyl]-4-(1-hydroxy-1-methylethyl)-2-furansulfonamide sodium salt, CP-456,773, CRID3
Molecular Weight 426.46 g/mol
CAS-No 256373-96-3
Restrictions For Research Use only
Format Solid
Handling Advice Protect from air and moisture
Storage -20 °C
Expiry Date 36 months