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  • 產品名稱：6-Aminonicotinamide

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  • 產品廠商：Biovision
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簡單介紹：
6-Aminonicotinamide
詳情介紹：
Characteristics

PubChem CID: 9500
Molecular Formula: C?H?N?O
Cell Premeable: Yes

Salt form: No

6-aminonicotinamide (6-AN) is inhibitor of glucose-6-phosphate dehydrogenase (G6PD), which catalyzes the conversion of G-6-P to 6-phosphogluconolactone, the first step of the pentose phosphate pathway. 6-AN has been widely used as a chemical tool in various experimental systems to study the biological consequences of inhibiting pentose phosphate pathway. Due to the essential roles of this pathway in generating reducing power (NADPH) and important metabolic intermediates (pentose-5-phosphate) for synthesis of macromolecules, it is not surprising that 6-AN exhibits anticancer activity in vitro, causes oxidative stress, and sensitizes cells to anticancer agents and radiation.

Smiles: C1=CC(=NC=C1C(=O)N)N

InChi: InChI=1S/C6H7N3O/c7-5-2-1-4(3-9-5)6(8)10/h1-3H,(H2,7,9)(H2,8,10)

Inchi Key: ZLWYEPMDOUQDBW-UHFFFAOYSA-N
Purity ≥ 98?% by HPLC
Chemical Name 6-amino-3-pyridinecarboxamide; 6-AN; NSC21206; SR4388
Formula C?H?N?O
Permeability Cell-permeable
Background Synonyms: 6-amino-3-pyridinecarboxamide, 6-AN, NSC21206, SR4388
Molecular Weight 137.1 g/mol
CAS-No 329-89-5
Restrictions For Research Use only
Format Solid
Handling Advice Protect from air and light
Storage -20 °C
Expiry Date 36 months