產(chǎn)品詳情

  • 產(chǎn)品名稱：2-Deoxy-D-Glucose

  • 產(chǎn)品型號：
  • 產(chǎn)品廠商：Biovision
  • 產(chǎn)品文檔：
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簡單介紹：
2-Deoxy-D-Glucose
詳情介紹：
Characteristics

PubChem CID: 439268
Molecular Formula: C?H??O?
Cell Premeable: Yes

Salt form: No

2-Deoxy-D-Glucose is a glucose analog that has long been known to act as a competitive inhibitor of glucose metabolism. Upon transport into the cells, 2-DG is phosphorylated by hexokinase to 2-DG-P. However, unlike G-6-P, 2-DG-P cannot be further metabolized by phosphohexose isomerase, which converts G-6-P to fructose-6-phosphate . 2-Deoxyglucose-P is trapped and accumulated in the cells, leading to inhibition of glycolysis mainly at the step of phosphorylation of glucose by hexokinase. Inhibition of this rate-limiting step by 2-DG causes a depletion of cellular ATP, leading to blockage of cell cycle progression and cell death in vitro.

Smiles: C1C(C(C(OC1O)CO)O)O

InChi: InChI=1S/C6H12O5/c7-2-4-6(10)3(8)1-5(9)11-4/h3-10H,1-2H2/t3-,4-,5?,6+/m1/s1

Inchi Key: PMMURAAUARKVCB-CERMHHMHSA-N
Purity ≥ 98?% GC
Chemical Name 2-Deoxy-D-arabinohexose, 2-Deoxyglucose
Formula C?H??O?
Permeability Cell-permeable
Background Synonyms: 2-Deoxy-D-arabinohexose, 2-Deoxyglucose
Molecular Weight 164.16 g/mol
CAS-No 154-17-6
Restrictions For Research Use only
Format Solid
Handling Advice Protect from air and moisture
Storage 4 °C
Expiry Date 36 months