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Purpose
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AZ-6102 is a potent TNKS1/2 inhibitor (Tankyrase)
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Characteristics
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AZ-6102 is a potent TNKS1/2 inhibitor (Tankyrase) that displays >100-fold selectivity against other poly (ADP-ribose) polymerase (PARP) family enzymes and inhibits Wnt pathway with IC?? value of 5 nM in DLD-1 cells. Inhibition of the PARP catalytic domain of the tankyrases is known to inhibit the Wnt pathway via increased stabilization of Axin. Wnt pathway plays important role in cancer, tissue homeostasis; germline mutations of various Wnt pathway components as Axin can lead to oncogenesis.
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Purity
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≥ 98?% by HPLC
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Chemical Name
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2-(4-(6-((3R,5S)-3,5-dimethylpiperazin-1-yl)-4-methylpyridin-3-yl)phenyl)-7-methyl-3,7-dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-one
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Formula
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C??H??N?O
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Permeability
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Cell-permeable
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Solubility
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DMSO(>20 mg/ml)
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