產(chǎn)品詳情

  • 產(chǎn)品名稱：AZ-5104

  • 產(chǎn)品型號(hào)：
  • 產(chǎn)品廠商：Biovision
  • 產(chǎn)品文檔：
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簡單介紹：
AZ-5104
詳情介紹：
Characteristics

PubChem CID: 71496460
Molecular Formula: C??H??N?O?
Cell Premeable: Yes

Salt form: No

AZ-5104 is an active, demethylated metabolite of AZD-9291 (Cat.No.2674). It displays similar overall activity profile with AZD-9291, but is more potent against mutant EGFR forms, while hitting the wild-type EGFR form at a lower concentration thus demonstrating a smaller selectivity margin compared with the parent. Like AZD-9291, AZ-5104 displays potent antitumor activities both in vitro and in vivo.

Smiles: CN(C)CCN(C)C1=CC(=C(C=C1NC(=O)C=C)NC2=NC=CC(=N2)C3=CNC4=CC=CC=C43)OC

InChi: InChI=1S/C27H31N7O2/c1-6-26(35)30-22-15-23(25(36-5)16-24(22)34(4)14-13-33(2)3)32-27-28-12-11-21(31-27)19-17-29-20-10-8-7-9-18(19)20/h6-12,15-17,29H,1,13-14H2,2-5H3,(H,30,35)(H,28,31,32)

Inchi Key: IQNVEOMHJHBNHC-UHFFFAOYSA-N
Purity ≥ 98?% by HPLC
Chemical Name N-(5-((4-(1H-indol-3-yl)pyrimidin-2-yl)amino)-2-((2-(dimethylamino)ethyl)(methyl)amino)-4-methoxyphenyl)acrylamide
Formula C??H??N?O?
Permeability Cell-permeable
Background Synonyms: N-(5-((4-(1H-indol-3-yl)pyrimidin-2-yl)amino)-2-((2-(dimethylamino)ethyl)(methyl)amino)-4-methoxyphenyl)acrylamide
Molecular Weight 485.58 g/mol
CAS-No 1421373-98-9
Restrictions For Research Use only
Format Solid
Handling Advice Protect from air and light
Storage -20 °C
Expiry Date 36 months