產(chǎn)品詳情

  • 產(chǎn)品名稱：GKT-137831

  • 產(chǎn)品型號：
  • 產(chǎn)品廠商：Biovision
  • 產(chǎn)品文檔：
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簡單介紹：
GKT-137831
詳情介紹：
Characteristics

PubChem CID: 58496428
Molecular Formula: C21H20ClN4O2
Cell Premeable: Yes

GKT-137831 is a novel pyrazolopyridinedione derivative that acts as a Nox4 and Nox1 inhibitor ((Ki 100-150 nM). GKT-137831 attenuates hypoxia-induced pulmonary vascular cell proliferation. Also a potent inhibitor of fibrosis and hepatocyte apoptosis.

Smiles: CN1C(=O)C=C2C(=C1C3=CC(=CC=C3)N(C)C)C(=O)N(N2)C4=CC=CC=C4Cl

InChi: InChI=1S/C21H19ClN4O2/c1-24(2)14-8-6-7-13(11-14)20-19-16(12-18(27)25(20)3)23-26(21(19)28)17-10-5-4-9-15(17)22/h4-12,23H,1-3H3

Inchi Key: RGYQPQARIQKJKH-UHFFFAOYSA-N
Purity ≥ 98?% by HPLC
Chemical Name 2-?(2-?chlorophenyl)-?4-?[3-?(dimethylamino)phenyl]-?5-?methyl-?1H-?pyrazolo[4,?3-?c]pyridine-?3,?6(2H,?5H)-?dione
Formula C21H20ClN4O2
Permeability Cell-permeable
Background Synonyms: 2-?(2-?chlorophenyl)-?4-?[3-?(dimethylamino)phenyl]-?5-?methyl-?1H-?pyrazolo[4,?3-?c]pyridine-?3,?6(2H,?5H)-?dione
Molecular Weight 394.85 g/mol
CAS-No 1218942-37-0
Restrictions For Research Use only
Format Solid
Handling Advice Protect from air and light
Storage -20 °C
Expiry Date 36 months