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  • 產品名稱：URMC-099

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  • 產品廠商：Biovision
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簡單介紹：
URMC-099
詳情介紹：
Characteristics

PubChem CID: 54764565
Molecular Formula: C??H??N?
Cell Premeable: Yes

URMC-099 is a brain-permeable, mixed lineage kinase (MLK) inhibitor with IC?? values of 19 nM, 42 nM, 14 nM, and 150 nM, for MLK1, MLK2, MLK3, and DLK, respectively. In vitro, URMC-099 treatment reduces inflammatory cytokine production by HIV-1 Tat-exposed microglia and prevents destruction and phagocytosis of cultured neuronal axons by these cells.

Smiles: CN1CCN(CC1)CC2=CC=C(C=C2)C3=CN=C4C(=C3)C(=CN4)C5=CC6=C(C=C5)NC=C6

InChi: InChI=1S/C27H27N5/c1-31-10-12-32(13-11-31)18-19-2-4-20(5-3-19)23-15-24-25(17-30-27(24)29-16-23)21-6-7-26-22(14-21)8-9-28-26/h2-9,14-17,28H,10-13,18H2,1H3,(H,29,30)

Inchi Key: QKKIWEILHCXECO-UHFFFAOYSA-N
Purity ≥ 98?% by HPLC
Chemical Name 3-(1H-indol-5-yl)-5-(4-((4-methylpiperazin-1-yl)methyl)phenyl)-1H-pyrrolo[2,3-b]pyridine
Formula C??H??N?
Permeability Cell-permeable
Background Synonyms: 3-(1H-indol-5-yl)-5-(4-((4-methylpiperazin-1-yl)methyl)phenyl)-1H-pyrrolo[2,3-b]pyridine
Molecular Weight 421.55 g/mol
CAS-No 1229582-33-5
Restrictions For Research Use only
Format Solid
Handling Advice Protect from air and light
Storage -20 °C
Expiry Date 36 months