產(chǎn)品詳情

  • 產(chǎn)品名稱：SU-5416

  • 產(chǎn)品型號：
  • 產(chǎn)品廠商：Biovision
  • 產(chǎn)品文檔：
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簡單介紹：
SU-5416
詳情介紹：
Characteristics

PubChem CID: 5329098
Molecular Formula: C??H??N?O
Cell Premeable: Yes

Salt form: N/A

SU-5416 is a potent tyrosine kinase inhibitor best known as an inhibitor of the vascular endothelial growth factor receptor (VEGFR-2, Flk-1/KDR). In addition to inhibiting VEGFR-2 (IC?? = 1 μM), SU-5416 also inhibits PDGFR (IC?? = 20 μM), c-Kit (IC?? = 30 nM), RET (IC?? = 170 nM), Flt-3 (IC?? = 160 nM), ABL (IC?? = 11 μM), and ALK (IC?? = 1.2 μM).SU 5416 does not inhibit epidermal growth factor (EGFR) or fibroblast growth factor receptor (FGFR) tyrosine kinases (IC?? > 100 μM). Acts as a suppressor of tumor vascularization, preventing the growth of multiple tumor types.

Smiles: CC1=CC(=C(N1)C=C2C3=CC=CC=C3NC2=O)C

InChi: InChI=1S/C15H14N2O/c1-9-7-10(2)16-14(9)8-12-11-5-3-4-6-13(11)17-15(12)18/h3-8,16H,1-2H3,(H,17,18)/b12-8-

Inchi Key: WUWDLXZGHZSWQZ-WQLSENKSSA-N
Purity ≥ 98?% by HPLC
Chemical Name 3-[(3,5-Dimethyl-1H-pyrrol-2-yl)methylene]-1,3-dihydro-2H-indol-2-one; Semaxinib
Formula C??H??N?O
Permeability Cell-permeable
Background Synonyms: 3-[(3,5-Dimethyl-1H-pyrrol-2-yl)methylene]-1,3-dihydro-2H-indol-2-one, Semaxinib
Molecular Weight 238.28 g/mol
CAS-No 204005-46-9
Restrictions For Research Use only
Format Solid
Handling Advice Protect from air and light
Storage -20 °C
Expiry Date 36 months