產(chǎn)品詳情

  • 產(chǎn)品名稱：SmoAntagonist,SA1

  • 產(chǎn)品型號：
  • 產(chǎn)品廠商：Biovision
  • 產(chǎn)品文檔：
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簡單介紹：
SmoAntagonist,SA1
詳情介紹：
Characteristics A Smoothened (Smo) antagonist. SA1 inhibits Hh pathway by interacting directly with Smo. Inhibits SAG (Smoothened agonist) activation of Hh signaling in Shh-LIGHT 2 cells (IC50 = 3.1 μM). Also inhibits the localization of Smo to cilia. Treatment of Ptch1-/- MEFs with SA1 suppresses the beta-galactosidase activity (IC50 = 3.8 μM) and inhibits the expression of Gli1 and Ptch1 in ASZ1 cells.
Synonyms: 3-(3-(4-Fluorophenyl)-2,5,7-trimethylpyrazolo[1,5a]pyrimidin-6-yl)-N-(4-(furan-2-yl)butan-2-yl)propanamide
Purity ≥ 95?% by NMR
Chemical Name 3-(3-(4-Fluorophenyl)-2,5,7-trimethylpyrazolo[1,5a]pyrimidin-6-yl)-N-(4-(furan-2-yl)butan-2-yl)propanamide
Formula C??H??FN?O?
Permeability Cell-permeable
Molecular Weight 448.53 g/mol
Restrictions For Research Use only
Format Solid
Handling Advice Protect from air and moisture
Storage -20 °C
Expiry Date 24 months
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image for Smo Antagonist, SA1 (ABIN1304106) Smo Antagonist, SA1