產(chǎn)品詳情

  • 產(chǎn)品名稱：SmoAntagonist,SA10

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  • 產(chǎn)品廠商：Biovision
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SmoAntagonist,SA10
詳情介紹：
Characteristics SA10 inhibits SAG (Smoothened agonist) activation of Hh signaling in Shh-LIGHT 2 cells (IC50 = 5 μM). However, unlike SA1 and SA9, Smo antagonist SA10 does not directly bind to Smo. Inhibits the localization o Smo to cilia. Also treatment of Ptch1-/- MEFs with SA10 suppresses the beta-galactosidase activity (IC50 = 11.0 μM) and inhibits the expression of Gli1 and Ptch1 in ASZ1 cells.
Synonyms: 4-((Benzo[c][1,2,5]thiadiazole-4-sulfonamido)methyl-N-(3-phenylpropyl)cyclohexanecarboxamide
Purity ≥ 95?% by NMR
Chemical Name 4-((Benzo[c][1,2,5]thiadiazole-4-sulfonamido)methyl-N-(3-phenylpropyl)cyclohexanecarboxamide
Formula C??H??N?O?S?
Permeability Cell-permeable
Molecular Weight 472.62 g/mol
Restrictions For Research Use only
Format Solid
Handling Advice Protect from air and moisture
Storage -20 °C
Expiry Date 24 months
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