產(chǎn)品詳情

  • 產(chǎn)品名稱：SmoAntagonist,SA9

  • 產(chǎn)品型號：
  • 產(chǎn)品廠商：Biovision
  • 產(chǎn)品文檔：
你添加了1件商品 查看購物車
簡單介紹：
SmoAntagonist,SA9
詳情介紹：
Characteristics SA9 inhibits Hh pathway by interacting directly with Smo. It inhibits SAG (Smoothened agonist) activation of Hh signaling in Shh-LIGHT 2 cells (IC50 = 19 μM). Induces the localization of Smo to cilia in ASZ1 cells, but not in IMCD3 cells. Also treatment of Ptch1-/- MEFs with SA9 suppresses the beta-galactosidase activity (IC50 = 1.0 μM) and inhibits the expression of Gli1 and Ptch1 in ASZ1 cells.
Synonyms: 3-(3-(4-Fluorophenyl)-5-oxo-4,5-dihydro-[1,2,4]triazolo[4,3-a]quinazolin-1-yl-N-(3-methylphenethyl)propanamide
Purity ≥ 95?% by NMR
Chemical Name 3-(3-(4-Fluorophenyl)-5-oxo-4,5-dihydro-[1,2,4]triazolo[4,3-a]quinazolin-1-yl-N-(3-methylphenethyl)propanamide
Formula C??H??ClN?O?
Permeability Cell-permeable
Molecular Weight 490 g/mol
Restrictions For Research Use only
Format Solid
Handling Advice Protect from air and moisture
Storage -20 °C
Expiry Date 24 months
Supplier Images
image for Smo Antagonist, SA9 (ABIN1304108) Smo Antagonist, SA9