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Characteristics
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FM-A13 is a selective inhibitor of Bruton's tyrosine kinase (BTK) IC50's = 2.5 μM (recombinant BTK) and 17.2 μM (human BTK). It has also been shown to inhibit Polo-like kinase (PLK) (IC50= 61 μM for human PLK3). It displays no activity (concentrations up to 278 μM) at JAK1, JAK3, HCK, EGFRK and IRK2 or CDK1-3, CHK1, IKK, MAPK1, SAPK2a and ten tyrosine kinases.
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