產(chǎn)品詳情

  • 產(chǎn)品名稱：BIIB021

  • 產(chǎn)品型號：
  • 產(chǎn)品廠商：Biovision
  • 產(chǎn)品文檔：
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簡單介紹：
BIIB021
詳情介紹：
Characteristics A synthetic, small molecule Hsp90 inhibitor that binds competitively with geldanamycin in the ATP-binding pocket of Hsp90. In tumor cells, BIIB021 induces the degradation of Hsp90 client proteins including HER-2, AKT, and Raf-1 and up-regulates expression of the heat shock proteins Hsp70 and Hsp27. BIIB021 inhibits the proliferation of N87, MCF-7, and BT474 tumor cells with IC50values of 0.06, 0.31, and 0.14 μM, respectively.
Purity ≥ 99?% by HPLC
Chemical Name 6-Chloro-9-[(4-methoxy-3,5-dimethyl--2-pyridinyl)methyl]-9H-purin-2-amine; CNF2024
Formula C??H??ClN?O
Permeability Cell-permeable
Molecular Weight 318.76 g/mol
CAS-No 848695-25-0
Restrictions For Research Use only
Format Solid
Handling Advice Protect from light and moisture
Storage -20 °C
Expiry Date 36 months
Supplier Images
image for BIIB 021 (ABIN1685600) BIIB 021