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  • 產(chǎn)品名稱:CombretastatinA4

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  • 產(chǎn)品廠商:Biovision
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CombretastatinA4
詳情介紹:
Characteristics A vascular disrupting, antineoplastic and microtubule-depolymerizing agent. Binds to tubulin dimers and prevents microtubule polymerization, resulting in mitotic arrest and apoptosis in endothelial cells. In addition, it disrupts the engagement of the endothelial cell-specific junctional molecule vascular endothelial-cadherin (VE-cadherin) and thus the activity of the VE-cadherin/beta-catenikt signaling pathway, which may result in the inhibition of endothelial cell migration and capillary tube formation.
Purity ≥ 98?% by HPLC
Chemical Name 2-Methoxy-5-[(1Z)-2-(3,4,5-trimetho-xyphenyl)ethenyl]phenol; CRC 87-09, NSC 817373
Formula C??H??O?
Permeability Cell-permeable
Molecular Weight 316.35 g/mol
CAS-No 117048-59-6
Restrictions For Research Use only
Format Solid
Handling Advice Protect from light and moisture
Storage -20 °C
Expiry Date 24 months
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