Characteristics
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Cell-permeable. A nitric oxide (NO) independent, superoxide-sensitive soluble guanylyl cyclase (sGC) activator (EC50 = 18 μM). Induces concentration-dependent increase in cGMP levels in cultured cells and in rabbit aortic rings. Inhibits platelet adhesion to collagen. A non-specific phosphodiesterase (PDE) inhibitor. YC-1 also inhibits HIF-alpha activity in tumors resulting in blocked angiogenesis and an inhibition of tumor growth. Inhibits Na+ channel. Synonyms: 3-(5'-Hydroxymethyl-2'-furyl)-1-benzylindazole
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