產(chǎn)品詳情

  • 產(chǎn)品名稱：AGI-5198

  • 產(chǎn)品型號：
  • 產(chǎn)品廠商：Biovision
  • 產(chǎn)品文檔：
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簡單介紹：
AGI-5198
詳情介紹：
Characteristics A potent, selective inhibitor of mutant IDH1 (isocitrate dehydrogenase 1). AGI-5198 inhibits IDH1 R132H and R132C mutants in vitro with IC50values of 0.07 and 0.16 μM, respectively, but not wild-type IDH1, wild-type IDH2, or IDH2 mutants (IC50s > 100 μM). Under conditions of near complete 2-HG (2-hydroxyglutarate) inhibition, AGI-5198 can induce demethylation of histone H3K9 me3 and expression.
Purity ≥ 98?% by HPLC
Chemical Name N-?[2-?(cyclohexylamino)-?1-?(2-?methylphenyl)-?2-?oxoethyl]-?N-?(3-?fluorophenyl)-?2-?methyl-?1H-?imidazole-?1-?acetamide; IDH-C35
Formula C??H??FN?O?
Permeability Cell-permeable
Molecular Weight 462.56 g/mol
CAS-No 1355326-35-0
Restrictions For Research Use only
Format Solid
Handling Advice Protect from light and moisture
Storage -20 °C
Expiry Date 36 months
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image for AGI-5198 (ABIN1685757) AGI-5198