產(chǎn)品詳情

  • 產(chǎn)品名稱：Dorsomorphin

  • 產(chǎn)品型號(hào)：
  • 產(chǎn)品廠商：Biovision
  • 產(chǎn)品文檔：
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Dorsomorphin
詳情介紹：
Characteristics Cell-permeable. A potent, selective, reversible and ATP-competitive inhibitor of AMP-activated protein kinase (AMPK) (Ki = 109 nM in the presence of 5 μM ATP and no AMP). Does not affect the activity on several structurally related kinases including JAK3, PKA, PKC, SYK and ZAPK. Also inhibits bone morphogenic protein (BMP) type I receptors (ALK2, ALK3 and ALK6). In addition, recently Dorsomorphin has shown to induce protective autophagy in cancer cells through AMPK inhibition-independent blockade of Akt/mTOR pathway.
Purity ≥ 98?% by HPLC
Chemical Name 6-[4-(2-Piperidin-1-yl)-ethoxy)-phenyl)]-3-pyridin-4-yl- pyrazolo[1,5-a]-pyrimidine; Compound C
Formula C??H??N?O
Permeability Cell-permeable
Molecular Weight 399.49 g/mol
CAS-No 866405-64-3
Restrictions For Research Use only
Format Solid
Handling Advice Protect from air and light
Storage 4 °C
Expiry Date 24 months
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image for Dorsomorphin (ABIN412288) Dorsomorphin