產(chǎn)品詳情

  • 產(chǎn)品名稱：Erlotinib,HydrochlorideSalt

  • 產(chǎn)品型號：
  • 產(chǎn)品廠商：Biovision
  • 產(chǎn)品文檔：
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簡單介紹：
Erlotinib,HydrochlorideSalt
詳情介紹：
Characteristics Erlotinib is an inhibitor of human Epidermal growth factor receptor (EGFR) tyrosine kinase (IC50 = 2 nM) and decreases EGFR autophosphorylation in tumor cells (IC50 = 20 nM). Studies in cell lines and enzyme assays have both shown that erlotinib inhibits EGFR at concentrations significantly lower than those needed to inhibit c-src and v-abl.
Purity ≥ 99?% by HPLC
Chemical Name CP-358774, OSI-774
Formula C??H??N?O?.HCl
Permeability Cell-permeable
Molecular Weight 429.9 g/mol
CAS-No 183319-69-9
Restrictions For Research Use only
Format Solid
Handling Advice Protect from light and moisture
Storage -20 °C
Expiry Date 24 months
Supplier Images
image for Erlotinib, Hydrochloride Salt (ABIN412173) Erlotinib, Hydrochloride Salt
Product cited in: Dayekh, Johnson-Obaseki, Corsten, Villeneuve, Sekhon, Weberpals, Dimitroulakos: "Monensin inhibits epidermal growth factor receptor trafficking and activation: synergistic cytotoxicity in combination with EGFR inhibitors." in: Molecular cancer therapeutics, Vol. 13, Issue 11, pp. 2559-71, 2014 (PubMed).

Cheng, Whitsett, Tran, Winkles: "The TWEAK Receptor Fn14 is a Src-inducible Protein and a Positive Regulator of Src-driven Cell Invasion." in: Molecular cancer research : MCR, 2014 (PubMed).