產(chǎn)品詳情

  • 產(chǎn)品名稱：CalpainInhibitorI,ALLN

  • 產(chǎn)品型號：
  • 產(chǎn)品廠商：Biovision
  • 產(chǎn)品文檔：
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簡單介紹：
CalpainInhibitorI,ALLN
詳情介紹：
Purpose A Calpain inhibitor
Sequence Ac-Leu-Leu-Nile-CHO
Characteristics A cell-permeable inhibitor of calpain I (Ki = 190 nM), calpain II (Ki = 220 nM), cathepsin B (Ki = 150 nM), and cathepsin L (Ki = 0.5 nM). Inhibits neutral cysteine proteases and the proteasome (Ki = 6 μM). Can initiate apoptosis in HL-60 cells but blocks dexamethasone-induced apoptosis in thymocytes and cycloheximide-induced apoptosis in metamyelocytes. Inhibits cyclin B degradation and arrests the cell cycle at G1/S and at meta-/anaphase.
Purity ≥ 95?% by HPLC
Chemical Name Ac-LLnL-CHO, MG-101, N-Acetyl-L-leucyl-L-leucyl-L-norleucinal, N-Acetyl-Leu-Leu-Nle-al
Formula C??H??N?O?
Permeability Cell-permeable
Solubility DMSO (25 mg/ml) or EtOH
Molecular Weight 383.54 g/mol
CAS-No 110044-82-1
Research Area Kinases/Phosphatases
Restrictions For Research Use only
Format Powder
Handling Advice Protect from moisture and air
Storage -20 °C
Expiry Date 24 months
Supplier Images
image for Calpain Inhibitor I, ALLN (ABIN629157) Calpain Inhibitor I, ALLN
Product cited in: Cho, Yoon, Kim, Woo, Rhee: "Circadian rhythm of hyperoxidized peroxiredoxin II is determined by hemoglobin autoxidation and the 20S proteasome in red blood cells." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 111, Issue 33, pp. 12043-8, 2014 (PubMed).