產(chǎn)品詳情

  • 產(chǎn)品名稱：EX-527

  • 產(chǎn)品型號(hào)：
  • 產(chǎn)品廠商：ArborAssays
  • 產(chǎn)品文檔：
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EX-527
詳情介紹：
Characteristics Selective SIRT1 inhibitor
Does not inhibit HDACs
Inhibitor of SIRT1 deacetylation of p53
Background EX-527 is a cell-permeable, selective inhibitor of SIRT1 (IC50 = 98 nM in vivo, 38nM in vitro) that does not inhibit histone deacetylase (HDAC) or other sirtuin deacetylase family members (IC50 values are 20 uM, 49 uM, > 100 uM and > 100 uM for SIRT2, SIRT3, HDAC and NADase respectively). EX-527 has been used to investigate the relationship between SIRT1-mediated deacetylation of p53, p53 activity, and cell survival following DNA damage.
Molecular Weight 284.71 kDa
CAS-No 49843-98-3
Restrictions For Research Use only
Storage 4 °C
Supplier Images
image for EX-527 (ABIN1439977) EX-527