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  • 產(chǎn)品名稱：ProteinKinaseN2(PKN2)(C-Term)Peptide

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簡單介紹：
ProteinKinaseN2(PKN2)(C-Term)Peptide
詳情介紹：
Blocked Antibody anti-PKN2 antibody (Protein Kinase N2) (C-Term) (ABIN2788942)
Sequence LRRNPERRLG AGEKDAEDVK KHPFFRLTDW SALMDKKVKP PFVPTIRGRE
Characteristics This is a synthetic peptide designed for use in combination with anti-Pkn2 Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
Purification Purified
Background Pkn2 is a PKC-related serine/threonine-protein kinase and Rho/Rac effector protein that participates in specific signal transduction responses in the cell. It plays a role in the regulation of cell cycle progression, actin cytoskeleton assembly, cell migration, cell adhesion, tumor cell invasion and transcription activation signaling processes. Pkn2 phosphorylates CTTN in hyaluronan-induced astrocytes and hence decreases CTTN ability to associate with filamentous actin, phosphorylates HDAC5, therefore lead to impair HDAC5 import. It is a direct RhoA target required for the regulation of the maturation of primordial junctions into apical junction formation in bronchial epithelial cells and is required for G2/M phases of the cell cycle progression and abscission during cytokinesis in a ECT2-dependent manner. It stimulates FYN kinase activity that is required for establishment of skin cell-cell adhesion during keratinocytes differentiation, regulates epithelial bladder cells speed and direction of movement during cell migration and tumor cell invasion, inhibits Akt pro-survival-induced kinase activity. It mediates Rho protein-induced transcriptional activation via the c-fos serum response factor (SRF).

Alias Symbols: 6030436C20Rik, AI507382, PRK2, Prkcl2, Stk7

Protein Size: 983
Molecular Weight 111 kDa
Gene ID 109333
NCBI Accession NM_178654, NP_848769
UniProt Q8BWW9
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Format Lyophilized
Reconstitution Add 100?μL of sterile PBS. Final peptide concentration is 1?mg/mL in PBS.
Concentration 1 mg/mL
Buffer Final peptide concentration is 1 mg/mL in PBS.
Handling Advice Avoid repeat freeze-thaw cycles.
Storage -20 °C
Storage Comment For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.