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  • 產(chǎn)品名稱：Mouseanti-HumanImmunoglobulinG4(IgG4)Antibody

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  • 產(chǎn)品廠商：NSJBio
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簡(jiǎn)單介紹：
Mouseanti-HumanImmunoglobulinG4(IgG4)Antibody
詳情介紹：
Immunogen A human recombinant protein corresponding to the Fc region was used as the immunogen for this IgG4 antibody.
Clone IHCG4-1
Isotype IgG1
Purification Protein G affinity chromatography
Alternative Name IgG4
Background The regions of relatively constant sequence beyond the variable regions of immunoglobulins are termed constant regions (C regions) and are present in both the heavy and light chains. With very few exceptions, the sites of attachment for carbohydrates on immunoglobulins are located in these C regions. These regions also function to hold the variable regions together by using the disulfide bond between them. The C regions facilitate interaction with the antigen by increasing the maximum rotation of the immunoglobulin arms. Reportedly, a large population of patients with recurrent respiratory tract infection has low IgG4 concentrations. IgG4-related sclerosing disease has been recognized as a systemic disease entity characterized by an elevated serum IgG4 level, sclerosing fibrosis, and diffuse lymphoplasmacytic infiltration with the presence of many IgG4-positive plasma cells. IgG4 is overexpressed in inflammatory pseudotumor (IPT) and under expressed in inflammatory myofibroblastic tumor (IMT). In pulmonary nodular lymphoid hyperplasia (PNLH), there are an increased number of IgG4+ plasma cells.
Gene ID 3503
Research Area Secondary Antibodies
Application Notes The concentration stated for each application is a general starting point. Variations in protocols, secondaries and substrates may require the IgG4 antibody to be titered up or down for optimal performance.

1. Staining of FFPE tissue is enhanced by boiling sections in 10?mM Tris with 1?mM EDTA,?pH 9 for 10-20?min followed by cooling at RT for 20?min.\. FACS: 0.5-1?μg/10^6 cells,IF: 1-2?μg/mL,IHC (FFPE): 0.5-1?μg/mL for 30?min at RT (1)
Restrictions For Research Use only
Buffer 1?mg/mL in 1X PBS, BSA free, sodium azide free
Preservative Azide free
Storage 4 °C,-20 °C
Storage Comment Store the IgG4 antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide).