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  • 產(chǎn)品名稱：Trametinib(GSK1120212)

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  • 產(chǎn)品廠商：TargetMol
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Trametinib(GSK1120212)
詳情介紹：
Purpose Trametinib is an orally bioavailable inhibitor of mitogen-activated protein kinase kinase (MEK MAPK/ERK kinase) with potential antineoplastic activity. Trametinib specifically binds to and inhibits MEK 1 and 2, resulting in an inhibition of growth factor-mediated cell signaling and cellular proliferation in various cancers. MEK 1 and 2, dual specificity threonine/tyrosine kinases often upregulated in various cancer cell types, play a key role in the activation of the RAS/RAF/MEK/ERK signaling pathway that regulates cell growth.
Characteristics Target: MEK inhibitor
Receptor: MEK1, MEK2
Purification All the products are sent with COA, HPLC and NMR inspection report to guarantee the quality.
Purity 98?%
Formula C26H23FIN5O4
Solubility Soluble in DMSO
Molecular Weight 615.39 g/mol
CAS-No 871700-17-3
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Format Solid
Storage -20 °C
Storage Comment For the majority of compounds, they could be dissolved in DMSO or other organic solvent.
Their stock solution can be stored at -20°C for up to 3 months and aliquoted for sampling convenience.
Several freeze/thaw cycles should not damage the activity of our small molecule products.
However, in many instances the aqueous solutions of some compounds need to be made fresh and cannot be stored. For these compounds, their solution should be prepared just before use and stored no longer than 24 hours.
Expiry Date 24 months