Purpose
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A cardiotonic glycoside obtained mainly from Digitalis lanata, it consists of three sugars and the aglycone digoxigenin. Digoxin has positive inotropic and negative chronotropic activity. It is used to control ventricular rate in atrial fibrillation and in the management of congestive heart failure with atrial fibrillation. Its use in congestive heart failure and sinus rhythm is less certain. The margin between toxic and therapeutic doses is small. (From Martindale, The Extra Pharmacopoeia, 30th ed, p666)
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Characteristics
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Tradename: LANOXIN Source of Compound: Digitalis lanata or D. orientalis Lam., Scrophulariaceae Target: ATPase inhibitor Receptor: Cholesterol side-chain cleavage enzyme,Na+, K+-ATPase Status: USP, INN, BAN, JAN
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Purification
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All the products are sent with COA, HPLC and NMR inspection report to guarantee the quality.
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Purity
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98?%
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Formula
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C41H64O14
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Solubility
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Water: 64.8 mg/L
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