產(chǎn)品詳情
所在位置: 首頁> 產(chǎn)品目錄> 試劑>

  • 產(chǎn)品名稱：Tandutinib(MLN518)

  • 產(chǎn)品型號(hào)：
  • 產(chǎn)品廠商：TargetMol
  • 產(chǎn)品文檔：
你添加了1件商品 查看購(gòu)物車
簡(jiǎn)單介紹：
Tandutinib(MLN518)
詳情介紹：
Purpose MLN518 is a novel, oral, small molecule designed to inhibit type III receptor tyrosine kinases, including FLT3, (platelet-derived growth-factor receptor) PDGFR and c-KIT. Tyrosine kinases are enzymes involved in several cellular processes and are known to be activated in cancer cells to drive tumor growth. AML patients with FLT3 mutations experience earlier disease relapse and shorter survival rates compared to patients without these mutations. Approximately 25 to 30 percent of all ***** AML patients have a mutation of the FLT3 gene. The use of MLN518 to treat AML has been granted fast-track status by the U.S. Food and Drug Administration. Phase I/II trials are underway.
Characteristics Tradename: ZUBRIN
Source of Compound: synthetic, CT-535-18, MLN-518
Target: KDR inhibitor,PDGFRβ inhibitor,CSF-1R inhibitor,c-Kit inhibitor,FLT3 inhibitor
Receptor: KDR,PDGFRβ,CSF-1R,c-Kit,FLT3
Status: USAN, INN
Purification All the products are sent with COA, HPLC and NMR inspection report to guarantee the quality.
Purity 99?%
Formula C31H42N6O4
Solubility DMSO 5 mg/mL,Ethanol 6 mg/mL
Molecular Weight 562.70 g/mol
CAS-No 387867-13-2
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Format Solid
Storage -20 °C
Storage Comment For the majority of compounds, they could be dissolved in DMSO or other organic solvent.
Their stock solution can be stored at -20°C for up to 3 months and aliquoted for sampling convenience.
Several freeze/thaw cycles should not damage the activity of our small molecule products.
However, in many instances the aqueous solutions of some compounds need to be made fresh and cannot be stored. For these compounds, their solution should be prepared just before use and stored no longer than 24 hours.
Expiry Date 24 months