產(chǎn)品詳情

  • 產(chǎn)品名稱：PX-478hydrochloride

  • 產(chǎn)品型號(hào)：
  • 產(chǎn)品廠商：Biovision
  • 產(chǎn)品文檔：
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簡單介紹：
PX-478hydrochloride
詳情介紹：
Characteristics

PubChem CID: 11234794
Molecular Formula: C??H??Cl?N?O
Cell Premeable: Yes

Salt form: No

PX-478 hydrochloride is an inhibitor of HIF-1α (IC?? of 20-30 μM) with potential antineoplastic activity. PX-478 inhibits HIF-1alpha protein levels and transactivation in a variety of cancer cell lines. The inhibitory effect of PX-478 on HIF-1alpha levels is primarily due to its inhibition of translation because HIF-1alpha translation continues in hypoxia when translation of most proteins is decreased.

Smiles: C1=CC(=CC=C1CC(C(=O)O)N)[N+](CCCl)(CCCl)[O-].Cl.Cl

InChi: InChI=1S/C13H18Cl2N2O3.2ClH/c14-5-7-17(20,8-6-15)11-3-1-10(2-4-11)9-12(16)13(18)19,/h1-4,12H,5-9,16H2,(H,18,19),2*1H/t12-,/m0../s1

Inchi Key: GIGCDIVNDFQKRA-LTCKWSDVSA-N
Purity ≥ 98?% by HPLC
Chemical Name (S)-4-(2-amino-2-carboxyethyl)-N,N-bis(2-chloroethyl)aniline oxide dihydrochloride
Formula C??H??Cl?N?O
Permeability Cell-permeable
Background Synonyms: (S)-4-(2-amino-2-carboxyethyl)-N,N-bis(2-chloroethyl)aniline oxide dihydrochloride
Molecular Weight 394.11 g/mol
CAS-No 685898-44-6
Restrictions For Research Use only
Format Solid
Handling Advice Protect from air and moisture
Storage -20 °C
Expiry Date 36 months