產(chǎn)品詳情

  • 產(chǎn)品名稱：Aprepitant

  • 產(chǎn)品型號：
  • 產(chǎn)品廠商：Biovision
  • 產(chǎn)品文檔：
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簡單介紹：
Aprepitant
詳情介紹：
Characteristics

PubChem CID: 6918365
Molecular Formula: C??H??F?N?O?
Cell Premeable: Yes

Salt form: No

Aprepitant is an anti-emetic compound that acts as a selective antagonist of human NK1 receptor (Kis = 3 and 454.1 nM for hNK1 and hNK3, respectively, IC?? = 0.09 nM for hNK1). Its prodrug is Fosaprepitant (Cat. No. 9529).

Smiles: CC(C1=CC(=CC(=C1)C(F)(F)F)C(F)(F)F)OC2C(N(CCO2)CC3=NC(=O)NN3)C4=CC=C(C=C4)F

InChi: InChI=1S/C23H21F7N4O3/c1-12(14-8-15(22(25,26)27)10-16(9-14)23(28,29)30)37-20-19(13-2-4-17(24)5-3-13)34(6-7-36-20)11-18-31-21(35)33-32-18/h2-5,8-10,12,19-20H,6-7,11H2,1H3,(H2,31,32,33,35)/t12-,19+,20-/m1/s1

Inchi Key: ATALOFNDEOCMKK-OITMNORJSA-N
Purity ≥ 98?% by HPLC
Chemical Name 5-?[[(2R,?3S)-?2-?[(1R)-?1-?[3,?5-?bis(trifluoromethyl)phenyl]ethoxy]-?3-?(4-?fluorophenyl)-?4-?morpholinyl]methyl]-?1,?2-?dihydro-?3H-?1,?2,?4-?triazol-?3-?one; Emend; L-754,030; MK-869; ONO-7436
Formula C??H??F?N?O?
Permeability Cell-permeable
Background Synonyms: 5-?[[(2R,?3S)-?2-?[(1R)-?1-?[3,?5-?bis(trifluoromethyl)phenyl]ethoxy]-?3-?(4-?fluorophenyl)-?4-?morpholinyl]methyl]-?1,?2-?dihydro-?3H-?1,?2,?4-?triazol-?3-?one, Emend, L-754,030, MK-869, ONO-7436
Molecular Weight 534.43 g/mol
CAS-No 170729-80-3
Restrictions For Research Use only
Format Solid
Handling Advice Protect from air and light
Storage -20 °C
Expiry Date 36 months