產(chǎn)品詳情

  • 產(chǎn)品名稱：L-189

  • 產(chǎn)品型號：
  • 產(chǎn)品廠商：Biovision
  • 產(chǎn)品文檔：
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簡單介紹：
L-189
詳情介紹：
Characteristics

PubChem CID: 824710
Molecular Formula: C??H??N?OS
Cell Premeable: Yes

Salt form: No

L-189 is a DNA ligase I, III and IV inhibitor (IC?? values are 5, 9 and 5 μM respectively) that blocks DNA binding (Ki= 5 μM for DNA ligase I). L-189 inhibits base excision repair (BER) and non-homologous end joining (NHEJ). L-189 specifically sensitizes cancer cells to DNA damage and increases the cytotoxicity of DNA-damaging agents.

Smiles: C1=CC=C(C=C1)C=NC2=C(NC(=S)NC2=O)N

InChi: InChI=1S/C11H10N4OS/c12-9-8(10(16)15-11(17)14-9)13-6-7-4-2-1-3-5-7/h1-6H,(H4,12,14,15,16,17)

Inchi Key: SAKOXVNKDMWWLF-UHFFFAOYSA-N
Purity ≥ 98?% by HPLC
Chemical Name (E)-6-amino-5-(benzylideneamino)-2-thioxo-2,3-dihydropyrimidin-4(1H)-one
Formula C??H??N?OS
Permeability Cell-permeable
Background Synonyms: (E)-6-amino-5-(benzylideneamino)-2-thioxo-2,3-dihydropyrimidin-4(1H)-one
Molecular Weight 246.29 g/mol
CAS-No 64232-83-3
Restrictions For Research Use only
Format Solid
Handling Advice Protect from air and light
Storage -20 °C
Expiry Date 36 months