產(chǎn)品詳情

  • 產(chǎn)品名稱：GSK-199hydrochloride

  • 產(chǎn)品型號：
  • 產(chǎn)品廠商：Biovision
  • 產(chǎn)品文檔：
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簡單介紹：
GSK-199hydrochloride
詳情介紹：
Characteristics

PubChem CID: N/A
Molecular Formula: C??H??ClN?O?
Cell Premeable: Yes

Salt form: No

GSK-199 is a potent, reversible inhibitor of PAD4 (IC?? = 200 nM. It binds to the low-calcium form of the enzyme and is selective for PAD4 over PAD1-3. It is less potent than the related PAD4 inhibitor GSK484 (IC?? = 50 nM). GSK-199 can inhibit the citrullination of PAD4 target proteins and diminish the formation of neutrophil extracellular traps in mouse neutrophils.

Smiles: O=C(N1C[C@H](N)CCC1)C2=CC(OC)=C3N(C)C(C4=CC5=CC=CN=C5N4CC)=NC3=C2.[H]Cl

InChi: InChI=1S/C24H28N6O2.ClH/c1-4-30-19(12-15-7-5-9-26-22(15)30)23-27-18-11-16(13-20(32-3)21(18)28(23)2)24(31)29-10-6-8-17(25)14-29,/h5,7,9,11-13,17H,4,6,8,10,14,25H2,1-3H3,1H/t17-,/m1./s1

Inchi Key: KRGMIOKDGHBYQE-UNTBIKODSA-N
Purity ≥ 98?%
Chemical Name (R)-(3-Aminopiperidin-1-yl)(2-(1-ethyl-1H-pyrrolo[2,3-b]pyridin-2-yl)-7-methoxy-1-methyl-1H-benzo[d]imidazol-5-yl)methanone hydrochloride
Formula C??H??ClN?O?
Permeability Cell-permeable
Background Synonyms: (R)-(3-Aminopiperidin-1-yl)(2-(1-ethyl-1H-pyrrolo[2,3-b]pyridin-2-yl)-7-methoxy-1-methyl-1H-benzo[d]imidazol-5-yl)methanone hydrochloride
Molecular Weight 468.98 g/mol
CAS-No 1549811-53-1
Restrictions For Research Use only
Format Solid
Handling Advice Protect from air and moisture
Storage -20 °C
Expiry Date 36 months