產(chǎn)品詳情

  • 產(chǎn)品名稱：AHU-377

  • 產(chǎn)品型號(hào)：
  • 產(chǎn)品廠商：Biovision
  • 產(chǎn)品文檔：
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簡(jiǎn)單介紹：
AHU-377
詳情介紹：
Characteristics

PubChem CID: 9811834
Molecular Formula: C??H??NO?
Cell Premeable: Yes

Salt form: No

AHU-377 is a prodrug that is activated in vivo by esterases to form an active compound LBQ657 which acts as a potent and selective neprilysin inhibitor. Neprilysin is a protease responsible for the degradation of atrial and brain natriuretic peptides. Inhibition of neprilysin prevents the degradation of natriuretic peptides and activates cGMP signaling pathways that regulate volume and blood pressure.

Smiles: CCOC(=O)C(C)CC(CC1=CC=C(C=C1)C2=CC=CC=C2)NC(=O)CCC(=O)O

InChi: InChI=1S/C24H29NO5/c1-3-30-24(29)17(2)15-21(25-22(26)13-14-23(27)28)16-18-9-11-20(12-10-18)19-7-5-4-6-8-19/h4-12,17,21H,3,13-16H2,1-2H3,(H,25,26)(H,27,28)/t17-,21+/m1/s1

Inchi Key: PYNXFZCZUAOOQC-UTKZUKDTSA-N
Purity ≥ 98?% by HPLC
Chemical Name 4-(((2S,4R)-1-([1,1'-biphenyl]-4-yl)-5-ethoxy-4-methyl-5-oxopentan-2-yl)amino)-4-oxobutanoate; Sacubitril
Formula C??H??NO?
Permeability Cell-permeable
Background Synonyms: 4-(((2S,4R)-1-([1,1'-biphenyl]-4-yl)-5-ethoxy-4-methyl-5-oxopentan-2-yl)amino)-4-oxobutanoate, Sacubitril
Molecular Weight 411.49 g/mol
CAS-No 149709-62-6
Restrictions For Research Use only
Handling Advice Protect from air and light
Storage -20 °C
Expiry Date 36 months